A selection of the PROLIFICA team publications

Arrow Screen and treat intervention for chronic hepatitis B in West Africa (Gambia and Senegal)

Next 1 Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants. Clin Gastroenterol Hepatol. 2021 Jan;19(1):46-60.e8.

Next 1 Prevalence of occult hepatitis B virus infection in adults: a systematic review and meta-analysis, The Lancet Gastroenterology & Hepatology, 2022.

Next 1 Clinical utility of quantifying hepatitis B surface antigen in African patients with chronic hepatitis B. J Viral Hepat. 2021 Jul;28(7):1003-1010.

Next 1 Prevalence and clinical significance of occult hepatitis B infection in The Gambia, West Africa. J Infect Dis. 2021

Next 1 Progress towards elimination goals for viral hepatitis. Nat Rev Gastroenterol Hepatol 17, 533–542, 2020.

Next 1 Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study. Lancet Global Health 2016

Next 1 Hepatitis B virus (HBV) infection amongst children in Senegal: current prevalence and seroprotection level. Pan African Journal, 2019.

Next 1 Prevention of Liver Fibrosis and Cancer in Africa: The PROLIFICA project - a collaborative study of hepatitis B-related liver disease in West Africa, S Afr Med J. 2015

Next 1 Hepatitis B testing and treatment in HIV patients in The Gambia-Compliance with international guidelines and clinical outcomes. Plos One 2017

Next 1 Improving communication about viral hepatitis in Africa. Lancet ID 2017

Next 1 Prevention of liver fibrosis and liver cancer linked to hepatitis B virus in Africa: the Prolifica study. Med Sci 2019

Arrow Prevention of HBV mother-to-child transmission in sub-Saharan Africa 

Next 1 Coverage and Timeliness of Birth Dose Vaccination in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2020 Jun 11;8(2):301.

Next 1 Coverage and Timeliness of Birth Dose Vaccination in Sub-Saharan Africa: A Systematic Review and Meta-Analysis Vaccines 2020

Next 1 Mother to child transmission of hepatitis B: What more needs to be done to eliminate it around the world? J Viral Hep 2019

Next 1 Mother-to-child transmission of hepatitis B in sub-Saharan Africa, Lancet Infect Dis. 2016

Next 1 Birth order and risk of hepatocellular carcinoma in chronic carriers of hepatitis B virus: a case-control study in The Gambia, Liver Int. 2015

Next 1 Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia, Gut 2016

Arrow HBV: simplified diagnostic algorithms

Next 1 Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data. Clin Gastroenterol Hepatol . 2020

 Next 1 Hepatitis B core-related antigen (HBcrAg): an alternative to HBV DNA to assess treatment eligibility in Africa Clin Infect Dis 2019.

Next 1 Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa. J Hepatol 2018

Next 1 Performance of two simplified HBV treatment criteria (TREAT-B score and WHO guidelines) in Burkina Faso, West Africa. J Hepatol. 2019. 

Next 1 Validation of rapid point-of-care (POC) tests for detection of hepatitis B surface antigen in field and laboratory settings in the Gambia, Western Africa, J Clin Microbiol. 2015

Next 1 The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa, Gut 2016

Next 1 Diagnostic accuracy of the gamma-glutamyl transpeptidase to platelet ratio (GPR) using transient elastography as a reference, Gut 2017

Arrow HCV in Africa

Next 1 Hepatitis C virus infection in people who inject drugs in Africa Lancet Infect Dis. 2020 Mar;20(3):282-283.

Next 1 Hepatitis C virus infection in people who inject drugs in Africa. Lancet Infect Dis. 2020 Mar;20(3):283-284.

Next 1 Clinical utility of HCV core antigen detection and quantification using serum samples and dired blood spots in people who inject drugs in Dar-es-Salaam, Tanzania, J Int AIDS Soc. 2017

Next 1 Scaling up HCV treatment in resource-limited countries. Nat Rev Gastroenterol Hepatol 2015.

Next 1 Role of hepatitis C virus core antigen assay in hepatitis C care in Africa, Lancet Gastroenterol Hepatol. 2018 

Next 1 High prevalence and poor linkage to care of transfusion-transmitted infections among blood donors in Dar-es-Salaam, Tanzania. J Viral hep 2019

Next 1 Scaling up prevention and treatment towards the elimination of hepatitis C: a global mathematical model. Lancet 2019

Arrow Biomakers of cirrhosis and hepatocellular carcinoma

Next 1 Hepatitis B virus preS2Δ38-55 variants: A newly identified risk factor for hepatocellular carcinoma. JHEP Rep. 2020 Jul 11;2(5):100144.

Next 1 Discovery and validation of urinary metabotypes for the diagnosis of heaptocellular carcinoma in West Africans, Hepatology 2014

Next 1 The prevalence and burden of symptoms in patients with chronic liver diseases in The Gambia, West Africa, Palliat Med. 2015

Next 1 Battelfield against hepatitis B infection and HCC in Africa, J Heptol. 2017

Next 1 Early age at diagnosis of hepatocellular carcinoma in sub-Saharan Africa, Lancet Gastroenterol Hepatol. 2017

Arrow Health economic analysis and global perspective

Next 1 Cost-effectiveness of community-based screening and treatment for chronic hepatitis B in The Gambia: an economic modelling analysis, Lancet Glob Health 2016

Next 1 Economic evaluations of HBV testing and treatment strategies and applicability to low and middle-income countries, BMC Infect Dis. 2017

Next 1 Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastro Hepatol 2019