A selection of the PROLIFICA team publications
Screen and treat intervention for chronic hepatitis B in West Africa (Gambia and Senegal)
Hepatitis B Core-Related Antigen to Indicate High Viral Load: Systematic Review and Meta-Analysis of 10,397 Individual Participants. Clin Gastroenterol Hepatol. 2021 Jan;19(1):46-60.e8.
Prevalence of occult hepatitis B virus infection in adults: a systematic review and meta-analysis, The Lancet Gastroenterology & Hepatology, 2022.
Clinical utility of quantifying hepatitis B surface antigen in African patients with chronic hepatitis B. J Viral Hepat. 2021 Jul;28(7):1003-1010.
Prevalence and clinical significance of occult hepatitis B infection in The Gambia, West Africa. J Infect Dis. 2021
Progress towards elimination goals for viral hepatitis. Nat Rev Gastroenterol Hepatol 17, 533–542, 2020.
Acceptability and feasibility of a screen-and-treat programme for hepatitis B virus infection in The Gambia: the Prevention of Liver Fibrosis and Cancer in Africa (PROLIFICA) study. Lancet Global Health 2016
Hepatitis B virus (HBV) infection amongst children in Senegal: current prevalence and seroprotection level. Pan African Journal, 2019.
Prevention of Liver Fibrosis and Cancer in Africa: The PROLIFICA project - a collaborative study of hepatitis B-related liver disease in West Africa, S Afr Med J. 2015
Hepatitis B testing and treatment in HIV patients in The Gambia-Compliance with international guidelines and clinical outcomes. Plos One 2017
Improving communication about viral hepatitis in Africa. Lancet ID 2017
Prevention of liver fibrosis and liver cancer linked to hepatitis B virus in Africa: the Prolifica study. Med Sci 2019
Prevention of HBV mother-to-child transmission in sub-Saharan Africa
Coverage and Timeliness of Birth Dose Vaccination in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. Vaccines (Basel). 2020 Jun 11;8(2):301.
Coverage and Timeliness of Birth Dose Vaccination in Sub-Saharan Africa: A Systematic Review and Meta-Analysis Vaccines 2020
Mother to child transmission of hepatitis B: What more needs to be done to eliminate it around the world? J Viral Hep 2019
Mother-to-child transmission of hepatitis B in sub-Saharan Africa, Lancet Infect Dis. 2016
Birth order and risk of hepatocellular carcinoma in chronic carriers of hepatitis B virus: a case-control study in The Gambia, Liver Int. 2015
Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia, Gut 2016
HBV: simplified diagnostic algorithms
Assay for Hepatitis B Core-related Antigen Identify Patients With High Viral Load: Systematic Review and Meta-analysis of Individual Participant Data. Clin Gastroenterol Hepatol . 2020
Hepatitis B core-related antigen (HBcrAg): an alternative to HBV DNA to assess treatment eligibility in Africa Clin Infect Dis 2019.
Development of a simple score based on HBeAg and ALT for selecting patients for HBV treatment in Africa. J Hepatol 2018
Performance of two simplified HBV treatment criteria (TREAT-B score and WHO guidelines) in Burkina Faso, West Africa. J Hepatol. 2019.
Validation of rapid point-of-care (POC) tests for detection of hepatitis B surface antigen in field and laboratory settings in the Gambia, Western Africa, J Clin Microbiol. 2015
The gamma-glutamyl transpeptidase to platelet ratio (GPR) predicts significant liver fibrosis and cirrhosis in patients with chronic HBV infection in West Africa, Gut 2016
Diagnostic accuracy of the gamma-glutamyl transpeptidase to platelet ratio (GPR) using transient elastography as a reference, Gut 2017
HCV in Africa
Hepatitis C virus infection in people who inject drugs in Africa Lancet Infect Dis. 2020 Mar;20(3):282-283.
Hepatitis C virus infection in people who inject drugs in Africa. Lancet Infect Dis. 2020 Mar;20(3):283-284.
Clinical utility of HCV core antigen detection and quantification using serum samples and dired blood spots in people who inject drugs in Dar-es-Salaam, Tanzania, J Int AIDS Soc. 2017
Scaling up HCV treatment in resource-limited countries. Nat Rev Gastroenterol Hepatol 2015.
Role of hepatitis C virus core antigen assay in hepatitis C care in Africa, Lancet Gastroenterol Hepatol. 2018
High prevalence and poor linkage to care of transfusion-transmitted infections among blood donors in Dar-es-Salaam, Tanzania. J Viral hep 2019
Scaling up prevention and treatment towards the elimination of hepatitis C: a global mathematical model. Lancet 2019
Biomakers of cirrhosis and hepatocellular carcinoma
Hepatitis B virus preS2Δ38-55 variants: A newly identified risk factor for hepatocellular carcinoma. JHEP Rep. 2020 Jul 11;2(5):100144.
Discovery and validation of urinary metabotypes for the diagnosis of heaptocellular carcinoma in West Africans, Hepatology 2014
The prevalence and burden of symptoms in patients with chronic liver diseases in The Gambia, West Africa, Palliat Med. 2015
Battelfield against hepatitis B infection and HCC in Africa, J Heptol. 2017
Early age at diagnosis of hepatocellular carcinoma in sub-Saharan Africa, Lancet Gastroenterol Hepatol. 2017
Health economic analysis and global perspective
Cost-effectiveness of community-based screening and treatment for chronic hepatitis B in The Gambia: an economic modelling analysis, Lancet Glob Health 2016
Economic evaluations of HBV testing and treatment strategies and applicability to low and middle-income countries, BMC Infect Dis. 2017
Accelerating the elimination of viral hepatitis: a Lancet Gastroenterology & Hepatology Commission. Lancet Gastro Hepatol 2019